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Identification of Core gene expression alterations regulated by gut microbiota in tumor progression and immunotherapy resistance through integrative pan-cancer analysis

18 Aug 2025

Abstract excerpt

Gut microbiota has been implicated in various diseases, exerting systemic effects on the host by activating or inhibiting gene expression. However, the precise role of gut microbiota and its downstream targets in hepatocellular carcinoma (HCC) progression remains poorly understood. To address this gap, we developed a computational method, termed the microbial-associated signature (MAS) score, to characterize gut...

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PMID: 40819753
DOI: 10.1016/j.ijbiomac.2025.146911

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