Article

Angiopoietin-like 4 shapes the intrahepatic T-cell landscape via eIF2α signaling during steatohepatitis in diet-induced NAFLD

2023-01-12

Abstract excerpt

<h4>ABSTRACT</h4> Adaptive T-cell immune response is essential in conferring protective immunity, a process requiring tight cellular homeostasis regulation. Pathological intrahepatic T-cell landscape has a role in NAFLD propagation; however, its activation remains unknown. To address this gap, we extensively characterized a novel diet-induced NAFLD murine model (LIDPAD) featuring key phenotypic and genetic attrib...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ae841184-e1df-5208-8453-943f2e2a1c5e
DOI: 10.1101/2023.01.10.523354

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Angiopoietin-like 4 shapes the intrahepatic T-cell landscape via eIF2α signaling during steatohepatitis in diet-induced NAFLDDOI 10.1101/2023.01.10.523354Read

Single-cell atlas of human liver and blood immune cells across fatty liver disease stages reveals distinct signatures linked to liver dysfunction and fibrogenesisSemantic proximity Read

Uncovering the Single-cell Transcriptomic Signatures and Pathogenesis of Mucosal-associated Invariant T cells during Nonalcoholic SteatohepatitisSemantic proximity Read

Interspecies NASH disease activity whole-genome profiling identifies a fibrogenic role of PPARα-regulated dermatopontinSemantic proximity Read

CD4 <sup>+</sup> T cells promote fibrosis during metabolic dysfunction-associated steatohepatitisSemantic proximity Read

Myeloid cells contribute to bystander CD8 T cell accumulation in metabolic-associated steatohepatitis and are sufficient for fibrosisSemantic proximity Read

Dysfunctional T Follicular Helper Cells Cause Intestinal and Hepatic Inflammation in NASHSemantic proximity Read

SteatoSITE: an Integrated Gene-to-Outcome Data Commons for Precision Medicine Research in NAFLDSemantic proximity Read

IL-32 is a stress-responsive node locked in a noncanonical NF-κB inflammatory loop during MASLD to HCC transitionSemantic proximity Read

Dual role of ANGPTL8 in promoting tumor cell proliferation and immune escape during hepatocarcinogenesisSemantic proximity Read

Understanding the cellular interactome of non-alcoholic fatty liver diseaseSemantic proximity Read

Primate-Specific LINC03040 Drives MASH Fibrosis via a Myeloid-Dependent Immuno-Metabolic AxisSemantic proximity Read

Single-cell transcriptome landscape of zebrafish liver reveals hepatocytes and immune cell interactions in understanding nonalcoholic fatty liver diseaseSemantic proximity Read