Article

Resistance to cortical amyloid-beta associates with cognitive health in centenarians

2023-12-29

Abstract excerpt

<h4>BACKGROUND</h4> Amyloid-beta(Aβ)-plaques accumulate in non-demented individuals, particularly at advanced ages. The unclear association between Aβ-pathology and cognition in elderly raises the question whether Aβ-pathology should be considered a benign consequence of aging. <h4>METHODS</h4> Post-mortem brains of 95 centenarians and 27 Alzheimer’s disease(AD) patients were evaluated for Aβ-plaque distribution a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ae706161-37ad-5095-8374-196c986cb154
DOI: 10.1101/2023.12.28.23300604

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 8 closest

Resistance to cortical amyloid-beta associates with cognitive health in centenariansDOI 10.1101/2023.12.28.23300604Read

Centenarians who avoid dementia.Semantic proximity Read

An autopsy case of a centenarian with the pathology of senile dementia of the neurofibrillary tangle type.Semantic proximity Read

Neocortical β-amyloid area is associated with dementia and APOE in the oldest-old.Semantic proximity Read

Alzheimer neuropathologic alterations in aged cognitively normal subjects.Semantic proximity Read

Cardiovascular risk in cognitively preserved elderlies is associated with glucose hypometabolism in the posterior cingulate cortex and precuneus regardless of brain atrophy and apolipoprotein gene variations.Semantic proximity Read

Cognitively Healthy Centenarians are genetically protected against Alzheimer’s disease specifically in immune and endo-lysosomal systemsSemantic proximity Read

Looking Behind the Curtain: Patient Stratification According to Genetic or Demographic Factors May Yield Unexpected Results in Studies of Neurodegenerative DiseasesSemantic proximity Read

Centenarians as Models of Resistance and Resilience to Alzheimer’s Disease and Related DementiasSemantic proximity Read