Article

Polymorphic Rescue of a Human Cytochrome P450 Pseudogene (CYP2B7) Reveals Functional Enzyme Activity in a Subset of Individuals

2026-02-27

Abstract excerpt

Cytochrome P450 (CYP) 2B7 is currently classified as a pseudogene due to the presence of a premature stop codon in exon 7 that is predicted to result in a truncated protein. We hypothesized that in some individuals, CYP2B7 may code for a full length protein with enzyme activity similar to CYP2B6, as the result of a DNA sequence polymorphism in the CYP2B7 premature stop codon. Genomic DNA was prepared from our huma...

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Literature Corpus work: ae5f9d67-f9f7-5bdd-81dd-f067b55a062e
DOI: 10.20944/preprints202602.1853.v1

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