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Article

Genes that drive the pathobiology of pediatric pulmonary arterial hypertension.

Pediatric pulmonology - 1 Mar 2021

Welch Carrie L, Austin Eric D, Chung Wendy K

Abstract excerpt

Emerging data from studies of pediatric-onset pulmonary arterial hypertension (PAH) indicate that the genomics of pediatric PAH is different than that of adults. There is a greater genetic burden in children, with rare genetic factors contributing to at least 35% of pediatric-onset idiopathic PAH (IPAH) compared with ~11% of adult-onset IPAH. De novo variants are the most frequent genetic cause of PAH in...

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Share to Bone Morphogenetic Protein Receptors, Type II
Share to Familial Primary Pulmonary Hypertension

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Deletion

Share to Heart Defects, Congenital

Share to Mutation, Missense

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Source

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Identifiers

PMID: 31917901
DOI: 10.1002/ppul.24637
PMCID: PMC7343584

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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