Article
[Hyaluronan, embryogenesis and morphogenesis].
Annales de dermatologie et de venereologie - 1 Apr 2010
Vabres P
Abstract excerpt
Hyaluronan is a major carbohydrate component of the extracellular matrix. Besides its structural role, it also appears to regulate cell transformation and migration during embryogenesis in vertebrates. Hyaluronan is synthesized by hyaluronan synthetases, transmembrane proteins expressed at several embryonic stages, as early as gastrulation. Inactivation or upregulation of hyaluronan synthetases elicits cardiac or...
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