Article
Phenotypic resistance in mycobacteria: is it because I am old or fat that I resist you?
The Journal of antimicrobial chemotherapy - 1 Oct 2015
Hammond Robert J H, Baron Vincent O, Oravcova Katarina, Lipworth Sam, Gillespie Stephen H
Abstract excerpt
OBJECTIVES: We aimed to explore the phenomenon of phenotypic resistance to antimycobacterial antibiotics and to determine whether this was associated with cell age or the presence of lipid bodies. METHODS: The accumulation of lipid-body-positive [lipid-rich (LR)] cells was followed using cell staining and flow cytometry. LR cells of Mycobacterium smegmatis, Mycobacterium marinum, Mycobacterium fortuitum and...
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