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Article

Recapitulation of Clinical Individual Susceptibility to Drug-Induced QT Prolongation in Healthy Subjects Using iPSC-Derived Cardiomyocytes.

Stem cell reports - 14 Feb 2017

Shinozawa Tadahiro, Nakamura Koki, Shoji Masanobu, Morita Maya, Kimura Maya, Furukawa Hatsue, Ueda Hiroki, Shiramoto Masanari, Matsuguma Kyoko, Kaji Yoshikazu, Ikushima Ippei, Yono Makoto, Liou Shyh-Yuh, Nagai Hirofumi, Nakanishi Atsushi, Yamamoto Keiji, Izumo Seigo

Abstract excerpt

To predict drug-induced serious adverse events (SAE) in clinical trials, a model using a panel of cells derived from human induced pluripotent stem cells (hiPSCs) of individuals with different susceptibilities could facilitate major advancements in translational research in terms of safety and pharmaco-economics. However, it is unclear whether hiPSC-derived cells can recapitulate interindividual differences in...

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Identifiers

PMID: 28111276
DOI: 10.1016/j.stemcr.2016.12.014
PMCID: PMC5312248

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