Article

Ginkgetin delays the progression of osteoarthritis by inhibiting the NF-κB and MAPK signaling pathways.

2024-10-28

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold> Osteoarthritis (OA) is considered an advancing chronic degenerative joint disease, leading to severe physical functional impairment of patients. Its development is closely related to increased inflammation and oxidative stress within the joint. Ginkgetin (GK), a natural non-toxic chemical, has proven anti-inflammatory, antioxidant, anti-tumor, and neuroprotective...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c39e4e52-8b27-5391-a854-75d5c3418b9a
DOI: 10.21203/rs.3.rs-5315063/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Ginkgetin delays the progression of osteoarthritis by inhibiting the NF-κB and MAPK signaling pathways.DOI 10.21203/rs.3.rs-5315063/v1Read

Network pharmacology, bioinformatics, molecular docking and experimental verification of the mechanism of HXZTS treatment on osteoarthritis synoviumSemantic proximity Read

A Network Pharmacology-based Study of the Potential Mechanism of Bushenhuoxue Formula in Treating OsteoarthritisSemantic proximity Read

Network Pharmacology Approach to Uncover the Mechanism Governing the Effect of Simiao Powder on Knee OsteoarthritisSemantic proximity Read

Cyanidin ameliorates the progression of osteoarthritis via the Sirt6/NF-κB axis in vitro and in vivoSemantic proximity Read

Yiqi Yangxue Qufeng Mixture alleviates knee osteoarthritis by modulating mitochondrialoxidative stress and suppressing ferroptosis via the PRKCA-MAPK/ERK axisSemantic proximity Read

Identification of the Resveratrol Potential Targets in the Treatment of OsteoarthritisSemantic proximity Read

Bioinformatics analysis and vivo experiment of Artemisia argyi essential oil for the treatment of pressure ulcer by modulating Wnt/β-catenin pathwaySemantic proximity Read

Systematic Pharmacology and Experimental Validation to Reveal the Alleviation of Astragalus membranaceus Regulating Ferroptosis in OsteoarthritisSemantic proximity Read

Role of Physical Exercise and Nutraceuticals in Modulating Molecular Pathways of OsteoarthritisSemantic proximity Read

Network Pharmacology and Metabolomic Effects in vivo of Fufang Duzhong Jiangu Granules for the Treatment of Kashin-Beck DiseaseSemantic proximity Read

The SRC/NF-κB-AKT/NOS3 Axis as a Key Mediator of Kaempferol’s Protective Effects against Oxidative Stress-induced OsteoclastogenesisSemantic proximity Read

Exploring the Mechanism of Tetramethylpyrazine in the Treatment of Osteoarthritis Based on Network PharmacologySemantic proximity Read