Article

Therapeutic Potential of AAV2-shmTOR Gene Therapy in Reducing Retinal Inflammation and Preserving Endothelial Integrity in Age-Related Macular Degeneration

2024-12-04

Abstract excerpt

<title>Abstract</title> <p>Age-related macular degeneration (AMD) is a prevalent retinal disorder that leads to central vision loss, mainly due to chronic inflammation. Tumor necrosis factor-alpha (TNF-α) is a critical mediator of inflammatory responses within the retinal environment. This study has investigated TNF-α's influence on inflammatory cytokine production and endothelial barrier integrity in human micro...

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Literature Corpus work: 33dfe3df-de8c-5048-b728-262df82c94aa
DOI: 10.21203/rs.3.rs-5150466/v1

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