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Oncolytic Adenovirus Armed with cGAS Activates STING Pathway and Enhances Antitumor Immunity in Lung Cancer with Superior Combined Efficacy of PD-L1 Therapy

2026-01-19

Abstract excerpt

The extensive expression of STING in patients with non - small cell lung cancer (NSCLC) is closely associated with overall survival and other factors. Activation of the STING pathway can suppress NSCLC. However, the clinical translation of STING agonists remains hindered by challenges such as off-target effects, metabolic instability, and suboptimal pharmacokinetics. In this study, we engineered two oncolytic aden...

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Literature Corpus work: ad4f1f8c-f71d-5332-871d-0784e60e4166
DOI: 10.64898/2026.01.15.699646

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