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The emergence of successful <i>Streptococcus pyogenes</i> lineages through convergent pathways of capsule loss and recombination directing high toxin expression

2019-06-27

Abstract excerpt

Gene transfer and homologous recombination in Streptococcus pyogenes has the potential to trigger the emergence of pandemic lineages, as exemplified by lineages of emm 1 and emm 89 that emerged in the 1980s and 2000s respectively. Although near-identical replacement gene transfer events in the nga (NADase) and slo (Streptolysin O) locus conferring high expression of these toxins underpinned the success of the...

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Literature Corpus work
aacc1e85-8f1c-5dd9-8418-b5c93e8ab4a3
DOI
10.1101/684167
Open publication

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The emergence of successful <i>Streptococcus pyogenes</i> lineages through convergent pathways of capsule loss and recombination directing high toxin expressionDOI 10.1101/684167
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