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Article

Natural variation of the streptococcal group A carbohydrate biosynthesis genes impacts host-pathogen interaction.

Microbial genomics - 1 Jul 2025

Schipper Kim, Tamminga Sara M, Murner Nicholas, Davies Matthew, Berkhout Paul, Bessen Debra E, Hendriks Astrid, Korotkova Natalia, Pannekoek Yvonne, van Sorge Nina M

Abstract excerpt

Streptococcus pyogenes is a leading cause of infection-related mortality in humans globally. The characteristic cell wall-anchored group A carbohydrate (GAC) is expressed by all S. pyogenes strains and consists of a polyrhamnose backbone with alternating N-acetylglucosamine (GlcNAc) side chains, of which 25% are decorated with glycerol phosphate (GroP). The genes in the gacA-L cluster are critical for GAC...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40673773
DOI: 10.1099/mgen.0.001443
PMCID: PMC12282279

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