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Article

Virulence Role of the GlcNAc Side Chain of the Lancefield Cell Wall Carbohydrate Antigen in Non-M1-Serotype Group AStreptococcus

7 Mar 2018

Abstract excerpt

ABSTRACT Classification of streptococci is based upon expression of unique cell wall carbohydrate antigens. All serotypes of group AStreptococcus(GAS;Streptococcus pyogenes), a leading cause of infection-related mortality worldwide, express the group A carbohydrate (GAC). GAC, the classical Lancefield antigen, is comprised of a polyrhamnose backbone withN-acetylglucosamine (GlcNAc) side chains. The immunodominant...

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PMID: 29382733
DOI: 10.1128/mbio.02294-17

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