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Article

Activated kinase screening identifies the IKBKE oncogene as a positive regulator of autophagy

5 Oct 2018

Abstract excerpt

Macroautophagy/autophagy is one of the major responses to stress in eukaryotic cells and is implicated in several pathological conditions such as infections, neurodegenerative diseases and cancer. Interestingly, cancer cells take full advantage of autophagy both to support tumor growth in adverse microenvironments and to oppose damages induced by anti-neoplastic therapies. Importantly, different human oncogenes...

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PMID: 30289335
DOI: 10.1080/15548627.2018.1517855

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