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Article

ERN1 and ALPK1 inhibit differentiation of bi-potential tumor-initiating cells in human breast cancer.

Oncotarget - 13 Dec 2016

Strietz Juliane, Stepputtis Stella S, Preca Bogdan-Tiberius, Vannier Corinne, Kim Mihee M, Castro David J, Au Qingyan, Boerries Melanie, Busch Hauke, Aza-Blanc Pedro, Heynen-Genel Susanne, Bronsert Peter, Kuster Bernhard, Stickeler Elmar, Brabletz Thomas, Oshima Robert G, Maurer Jochen

Abstract excerpt

Cancers are heterogeneous by nature. While traditional oncology screens commonly use a single endpoint of cell viability, altering the phenotype of tumor-initiating cells may reveal alternative targets that regulate cellular growth by processes other than apoptosis or cell division. We evaluated the impact of knocking down expression of 420 kinases in bi-lineage triple-negative breast cancer (TNBC) cells that...

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Identifiers

PMID: 27829216
DOI: 10.18632/oncotarget.13086
PMCID: PMC5347769

Genes

ERN1
ALPK1
GATA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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