Article
MYC disrupts transcriptional and metabolic circadian oscillations in cancer and promotes enhanced biosynthesis
2023-01-03
Abstract excerpt
The molecular circadian clock, which controls rhythmic 24-hour oscillation of genes, proteins, and metabolites in healthy tissues, is disrupted across many human cancers. Deregulated expression of the MYC oncoprotein has been shown to alter expression of molecular clock genes, leading to a disruption of molecular clock oscillation across cancer types. It remains unclear what benefit cancer cells gain from suppress...
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Identifiers and source
- Literature Corpus work
- ad099ff6-1a1d-506b-9454-e3b4d02c29d2
- DOI
- 10.1101/2023.01.03.522637