Article

Disruption of endothelial stability directly impacts vascular neighboring cells in Hereditary Hemorrhagic Telangiectasia

2026-05-09

Abstract excerpt

<h4>BACKGROUND</h4> Hereditary hemorrhagic telangiectasia (HHT) is a genetic disorder caused by pathogenic variants in the endothelial TGFβ/BMP pathway, crucial for the vascular arterial-venous differentiation. Vascular defects result in fragile and malformed vessels. The precise mechanisms driving vascular network failure remain incompletely understood, complicating the design of targeted therapies. <h4>METHODS<...

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Literature Corpus work: c4017813-879e-5c79-99fc-1d477981cc0d
DOI: 10.64898/2026.05.05.723108

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