Article

Vitreous fluid-isolated DNA for the genetic analysis of primary uveal melanoma: a proof-of-concept study

2024-02-10

Abstract excerpt

<h4>Background</h4> Uveal melanoma is an aggressive ocular malignancy. Early molecular characterisation of primary tumours is crucial to identify those at risk of metastatic dissemination. Although tumour biopsies are being taken, liquid biopsies of ocular fluids may form a less invasive but relatively unexplored alternative. In this study, we aim to evaluate the DNA content of vitreous fluid from eyes with a uvea...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: acbc2b0c-eae7-5771-9c28-53f1ec098b18
DOI: 10.1101/2024.02.09.24302604

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Vitreous fluid-isolated DNA for the genetic analysis of primary uveal melanoma: a proof-of-concept studyDOI 10.1101/2024.02.09.24302604Read

Identification of clinically-relevant genetic alterations in uveal melanoma using RNA sequencingSemantic proximity Read

Presence of tumor DNA in aqueous humor is correlated with high risk uveal melanomaSemantic proximity Read

Circulating tumor DNA tracking through driver mutations as a liquid biopsy-based biomarker for uveal melanoma.Semantic proximity Read

Potential of Aqueous Humor as a Liquid Biopsy for Uveal Melanoma.Semantic proximity Read

Genomic, prognostic, and cell-signaling advances in uveal melanoma.Semantic proximity Read

Circulating Tumor DNA Monitoring in Patients with Uveal Melanoma Using Mutation-Agnostic Multiplex Drop-Off ddPCR Assays.Semantic proximity Read

Digital PCR-based deep quantitative profiling delineates heterogeneity and evolution of uveal melanomaSemantic proximity Read

Molecular profiling of driver events and tumor-infiltrating lymphocytes in metastatic uveal melanomaSemantic proximity Read

Targeted Next-Generation Sequencing of 117 Routine Clinical Samples Provides Further Insights into the Molecular Landscape of Uveal MelanomaSemantic proximity Read

Detection of the Uveal Melanoma-Associated Mutation GNAQ Q209P from Liquid Biopsy Using CRISPR/Cas12a Technology.Semantic proximity Read

Pathological and Molecular Diagnosis of Uveal MelanomaSemantic proximity Read

Combined mutation and copy-number variation detection by targeted next-generation sequencing in uveal melanoma.Semantic proximity Read