Article
Digital PCR-based genetic profiling from vitreous fluid as liquid biopsy for primary uveal melanoma: a proof-of-concept study.
Journal of experimental & clinical cancer research : CR - 17 Apr 2025
Nell R J, Versluis M, Menger N V, Gelmi M C, Vu T H K, Verdijk R M, Luyten G P M, Jager M J, van der Velden P A
Abstract excerpt
BACKGROUND: Uveal melanoma is an aggressive ocular malignancy. Early molecular characterisation of primary tumours is crucial to identify those at risk of metastatic dissemination. Although tumour biopsies are being taken, liquid biopsies of ocular fluids may form a less invasive but relatively unexplored alternative. In this study, we aim to evaluate the DNA content of vitreous fluid from eyes with a uveal...
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- Humans
- Melanoma
- Uveal Neoplasms
- Uveal Melanoma
- Liquid Biopsy
- Male