Article

Mineralized Tissue-Targeting Expression System for Local Control of Gene Expression

2025-11-28

Abstract excerpt

Targeted control of gene expression in mineralized tissue would enable the use of nucleic acids to modulate the local microenvironment at diseased sites, ultimately promoting bone regeneration. Piperazine-linked bisphosphonate ionizable lipids provide a facile approach to targeting the transfection of mineralized tissue with lipid nanoparticles (LNPs). Here, we develop a Mineralized Tissue-Targeting Expression Sys...

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Literature Corpus work: aca47815-e3ce-521f-8d28-327350e2d45c
DOI: 10.1101/2025.11.25.690451

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