Article

Dual-Targeted, Stimuli-Responsive PLGA Nanoparticles for Osteoporosis: Co-Functionalization with Bone- and Osteoclast-Specific Ligands Enables Controlled Risedronate Delivery

2025-04-30

Abstract excerpt

Osteoporosis is a widespread skeletal disease characterized by low bone mass and microarchitectural deterioration, leading to fragile bones and high fracture risk[1]. Current therapies, such as bisphosphonates and RANKL inhibitors, are effective at reducing bone loss but suffer from poor targeting, low oral bioavailability[2], and significant side effects. We propose a novel nanoparticle-based therapeutic strategy...

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Literature Corpus work: 995fc5fd-a339-5948-8619-dc7c26556c32
DOI: 10.20944/preprints202504.2549.v1

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Dual-Targeted, Stimuli-Responsive PLGA Nanoparticles for Osteoporosis: Co-Functionalization with Bone- and Osteoclast-Specific Ligands Enables Controlled Risedronate DeliveryDOI 10.20944/preprints202504.2549.v1Read

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