Article

Chromatin compartment dynamics in a haploinsufficient model of cardiac laminopathy

2019-02-19

Abstract excerpt

Pathogenic mutations in A-type nuclear lamins cause dilated cardiomyopathy, which is postulated to result from dysregulated gene expression due to changes in chromatin organization into active and inactive compartments. To test this, we performed genome-wide chromosome conformation analyses (Hi-C) in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) with a haploinsufficient mutation for lamin...

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Literature Corpus work: ac72b072-6abf-5d14-943b-ef302e752fe1
DOI: 10.1101/555250

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