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Article

3'UTR variants of ALS-linked RNAs modify subcellular and cellular phenotypes.

The FEBS journal - 1 Apr 2026

Savasan-Sogut Melis, Campos-Melo Danae, Strong Michael J

Abstract excerpt

While most human genes express mRNA 3'untranslated region (3'UTR) variants of different lengths, their impact on cell physiology and disease remains largely unknown. Here, we studied 3'UTR length heterogeneity in amyotrophic lateral sclerosis (ALS) and determined that three ALS-linked transcripts exhibit lengthening of their 3'UTRs in patient samples. We investigated phenotypical effects in a neuronal cell line...

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Identifiers

PMID: 41387380
DOI: 10.1111/febs.70364
PMCID: PMC13080226

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NEFH

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