Article

ADGRG6 promotes adipogenesis and is involved in sex-specific fat distribution

2022-06-29

Abstract excerpt

Fat distribution differences between males and females are a major risk factor for metabolic disease, but their genetic etiology remains largely unknown. Here, we establish ADGRG6 as a major factor in adipogenesis and gender fat distribution. Deletion of ADGRG6 in human adipocytes impairs adipogenesis due to reduced cAMP signaling. Conditionally knocking out Adgrg6 in mouse adipocytes or deleting an intronic en...

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Literature Corpus work: ac5e106c-d532-5a5c-ae0d-72cc98d0b2c5
DOI: 10.1101/2022.06.24.497411

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