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Article

Androgen Receptor is a Negative Regulator of PRDM16 in Beige Adipocyte

21 May 2023

Abstract excerpt

PRDM16 (PR domain containing protein 16) serves as a dominant activator of brown and beige adipocyte. However, mechanisms underlying the regulation of PRDM16 expression are incompletely understood. A Prdm16 luciferase knockin reporter mouse model is generated, enabling high throughput monitoring of Prdm16 transcription. Single clonal analysis reveals high heterogeneity of Prdm16 expression in the inguinal white...

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Share to Adipokines, Inflammation, and Metabolic Diseases
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PMID: 37211698
DOI: 10.1002/advs.202300070

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