Article

Shared trans-ancestry architecture of HLA-mediated disease risk in the All of Us Research Program

2026-07-14

Abstract excerpt

<title>Abstract</title> <p> The human leukocyte antigen (HLA) region is the strongest genetic contributor to many immune-mediated diseases, yet whether HLA architecture is shared across ancestries remains unclear. We analyzed high-resolution HLA variation in 390,823 participants from the <italic>All of Us</italic> Research Program spanning six genetic ancestry groups, including 262,915 with linked electronic h...

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Literature Corpus work: ac50779d-03a0-5bd4-8819-6a649a09be34
DOI: 10.21203/rs.3.rs-10157403/v1

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