Article
LD-transpeptidation is crucial for fitness and polar growth in Agrobacterium tumefaciens.
PLoS genetics - 1 Oct 2024
Aliashkevich Alena, Guest Thomas, Alvarez Laura, Gilmore Michael C, Rea Daniel, Amstutz Jennifer, Mateus André, Schiffthaler Bastian, Ruiz Iñigo, Typas Athanasios, Savitski Mikhail M, Brown Pamela J B, Cava Felipe
Abstract excerpt
Peptidoglycan (PG), a mesh-like structure which is the primary component of the bacterial cell wall, is crucial to maintain cell integrity and shape. While most bacteria rely on penicillin binding proteins (PBPs) for crosslinking, some species also employ LD-transpeptidases (LDTs). Unlike PBPs, the essentiality and biological functions of LDTs remain largely unclear. The Hyphomicrobiales order of the...
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