Article

Scoring gene importance by interpreting single-cell foundation models

2025-06-20

Abstract excerpt

Determining a gene’s functional significance within a cellular context has long been a challenge, as absolute expression level is an unreliable indicator. We introduce SIGnature, a framework for scoring gene importance by leveraging attributions derived from single-cell RNA-sequencing (scRNA-seq) foundation models. Attribution scores reduce technical noise, emphasize regulatory genes, and facilitate cross-dataset...

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Literature Corpus work: da404028-6df5-5895-a2d3-adf1cf3ea0b9
DOI: 10.1101/2025.06.14.659567

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