Article

Spatial genomic, biochemical, and cellular mechanisms drive meningioma heterogeneity and evolution

2023-05-15

Abstract excerpt

<title>Abstract</title> <p>Intratumor heterogeneity underlies cancer evolution and treatment resistance<sup>1–5</sup>, but targetable mechanisms driving intratumor heterogeneity are poorly understood. Meningiomas are the most common primary intracranial tumors and are resistant to all current medical therapies<sup>6,7</sup>. High-grade meningiomas cause significant neurological morbidity and mortality and are dis...

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Literature Corpus work: 1a2da7cb-d8dd-5d57-b6c8-2a882078b948
DOI: 10.21203/rs.3.rs-2921804/v1

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