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Hypermitotic meningiomas harbor DNA methylation subgroups with distinct biological and clinical features

30 Sept 2022

Abstract excerpt

BACKGROUND: Meningiomas, the most common primary intracranial tumors, can be separated into 3 DNA methylation groups with distinct biological drivers, clinical outcomes, and therapeutic vulnerabilities. Alternative meningioma grouping schemes using copy number variants, gene expression profiles, somatic short variants, or integrated molecular models have been proposed. These data suggest meningioma DNA...

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PMID: 36227281
DOI: 10.1093/neuonc/noac224

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