Article
RNA splicing as a biomarker and phenotypic driver of meningioma DNA-methylation groups.
Neuro-oncology - 5 Dec 2024
Leclair Nathan K, Choudury Abrar, Chen William C, Magill Stephen T, McCortney Kathleen, Horbinski Craig M, Chen Zhenhong, Goldschmidt Ezequiel, Eaton Charlotte D, Bulsara Ketan R, Bi Wenya Linda, Patel Akash J, Sahm Felix, Raleigh David, Anczukow Olga
Abstract excerpt
BACKGROUND: Advances in our understanding of the molecular biology of meningiomas have led to significant gains in the ability to predict patient prognosis and tumor recurrence and to identify novel targets for therapeutic design. Specifically, classification of meningiomas based on DNA methylation has greatly improved our ability to risk stratify patients, however new questions have arisen in terms of the...
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