Article

Bridge nucleic acid/DNA gapmers as inhibitors of gene expression by multiple antisense mechanisms

2025-09-03

Abstract excerpt

<title>Abstract</title> <p>Antisense interference with gene expression is usually achieved using nuclease-resistant oligonucleotide analogs that act by mRNA degradation, recruiting endogenous RNase H or RNase P, or steric hindrance of translation. Bridge nucleic acids (BNAs) are promising nucleotide analogs, and their chemical structure allows the development of new variants. Building on previous research, we eva...

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Literature Corpus work: abb01bbf-bd61-526e-b537-b65f1f07f5fb
DOI: 10.21203/rs.3.rs-7390173/v1

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