Article

uORF-targeting steric block antisense oligonucleotides do not reproducibly activate RNASEH1 expression

2024-06-14

Abstract excerpt

Upstream open reading frames (uORFs) are cis -regulatory motifs that are predicted to occur in the 5ʹ untranslated region (UTR) of the majority of human protein-coding transcripts. uORFs are typically associated with repression of the downstream primary open reading frame (pORF) at either the level of translation, or by promoting mRNA turnover via the nonsense-mediated decay pathway. Interference with uORF activi...

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Literature Corpus work: 8bf5956a-5f22-5984-9094-1f651730dc23
DOI: 10.1101/2024.06.14.598998

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