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mRNA-Based Vaccines are Highly Immunogenic and Confer Protection in the Gnotobiotic Pig Model of Human Rotavirus Diarrhea

2024-02-02

Abstract excerpt

Human rotavirus (HRV) is still a leading cause of severe dehydrating gastroenteritis globally, particularly in infants and children. Previously, we demonstrated immunogenicity of mRNA-based HRV vaccine candidates expressing the viral spike protein VP8* in rodent models. In the present study, we assessed the immunogenicity and protective efficacy of two mRNA-based HRV trivalent vaccine candidates, encoding VP8* of...

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Literature Corpus work
abaa8fb6-9224-5857-aa15-0f083397e89b
DOI
10.20944/preprints202402.0160.v1
Open publication

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mRNA-Based Vaccines are Highly Immunogenic and Confer Protection in the Gnotobiotic Pig Model of Human Rotavirus DiarrheaDOI 10.20944/preprints202402.0160.v1
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