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Article

mRNA-based VP8* nanoparticle vaccines against rotavirus are highly immunogenic in rodents

21 Dec 2023

Abstract excerpt

Despite the availability of live-attenuated oral vaccines, rotavirus remains a major cause of severe childhood diarrhea worldwide. Due to the growing demand for parenteral rotavirus vaccines, we developed mRNA-based vaccine candidates targeting the viral spike protein VP8*. Our monomeric P2 (universal T cell epitope)-VP8* mRNA design is equivalent to a protein vaccine currently in clinical development, while LS...

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PMID: 38129390
DOI: 10.1038/s41541-023-00790-z

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