Article
Cupric ions induce the oxidation and trigger the aggregation of human superoxide dismutase 1.
PloS one - 1 Jan 2013
Li Cheng, Xu Wen-Chang, Xie Zhen-Sheng, Pan Kai, Hu Jiao, Chen Jie, Pang Dai-Wen, Yang Fu-Quan, Liang Yi
Abstract excerpt
BACKGROUND: Amyotrophic lateral sclerosis (ALS), partly caused by the mutations and aggregation of human copper, zinc superoxide dismutase (SOD1), is a fatal degenerative disease of motor neurons. Because SOD1 is a major copper-binding protein present at relatively high concentration in motor neurons and copper can be a harmful pro-oxidant, we want to know whether aberrant copper biochemistry could underlie ALS...
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