Article

Binding to Albumin and Off-Target Toxicity Confound the Use of LRRC8/VRAC Channel Blockers in Cell Physiology Assays

2026-07-19

Abstract excerpt

<h4>ABSTRACT</h4> Volume-regulated anion channels (VRACs), formed by leucine-rich repeat-containing 8 (LRRC8) proteins, are ubiquitously expressed chloride channels essential for cell volume regulation and implicated in diverse physiological and pathological processes. Small-molecule VRAC inhibitors have been reported to modulate paracrine signaling, proliferation, differentiation, migration, and apoptosis, and h...

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Literature Corpus work: ab68fb3e-b1e0-54c3-82de-8a049e000d2b
DOI: 10.64898/2026.07.13.737859

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