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The Spike protein of SARS-CoV-2 impairs lipid metabolism and increases susceptibility to lipotoxicity: implication for a role of Nrf2

2022-04-19

Abstract excerpt

<h4>Background/objectives</h4> Coronavirus disease 2019 (COVID-19) patients exhibit lipid metabolic alterations, but the mechanism remains unknown. In this study, we aimed to investigate whether the Spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) impairs lipid metabolism in host cells. <h4>Methods</h4> A Spike cell line in HEK293 was generated using the pcDNA vector carrying the Spi...

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Identifiers and source

Literature Corpus work
ab506916-a2c8-5a8e-b468-199c04a28a8a
DOI
10.1101/2022.04.19.488806
Open publication

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The Spike protein of SARS-CoV-2 impairs lipid metabolism and increases susceptibility to lipotoxicity: implication for a role of Nrf2DOI 10.1101/2022.04.19.488806
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