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Pyroptosis of syncytia formed by fusion of SARS-CoV-2 spike and ACE2-expressing cells

24 Aug 2021

Abstract excerpt

Coronavirus Disease 2019 (COVID-19) is an infectious disease associated with systematical multi-organ failure caused by SARS-CoV-2, which mainly infects the lung and upper respiratory system 1 , 2 . Massive multinucleated syncytia are commonly observed in autopsy of severe COVID-19 patients 3 . It has been reported that the interaction between Spike (S) protein and ACE2 not only mediated the fusion of virus with...

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PMID: 34429403
DOI: 10.1038/s41421-021-00310-0

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