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SARS-CoV-2 ORF3a sensitizes cells to ferroptosis via Keap1-NRF2 axis

23 May 2023

Abstract excerpt

Viral infection-induced cell death has long been considered as a double-edged sword in the inhibition or exacerbation of viral infections. Patients with severe Coronavirus Disease 2019 (COVID-19) are characterized by multiple organ dysfunction syndrome and cytokine storm, which may result from SARS-CoV-2-induced cell death. Previous studies have observed enhanced ROS level and signs of ferroptosis in SARS-CoV-2...

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PMID: 37245288
DOI: 10.1016/j.redox.2023.102752

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