Article

Human PBMCs Form Lipid Droplets in Response to Spike Proteins

2023-07-25

Abstract excerpt

Intracellular lipid droplets (LDs) can occur in response to inflammation, metabolic stresses, and other physiological/pathological processes. Herein, we investigated whether spike proteins of SARS-CoV-2 induce LDs in human peripheral blood mononuclear cells (PBMCs) and in pulmonary microvascular endothelial cells (HPMEC). PBMCs or HPMEC were incubated alone or with endotoxin-free recombinant variants of trimeric s...

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Literature Corpus work: 49c1b872-8987-56ad-ac8d-49515f263e2b
DOI: 10.20944/preprints202307.1638.v1

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