Article

Role and mechanism of palmitic acid-regulated palmitoylation modification of SEC63 protein during endoplasmic reticulum stress in Human Ovarian Granulosa Tumor Cells (KGN)

2025-09-12

Abstract excerpt

<title>Abstract</title> <p>Objective To investigate the role and mechanism of palmitic acid (PA)-regulated palmitoylation modification of SEC63 protein during endoplasmic reticulum (ER) stress in human ovarian granulosa tumor cells (KGN). Methods Serum samples were collected from 22 patients with polycystic ovary syndrome (PCOS) and 20 control subjects undergoing in vitro fertilization. Metabolomic analysis was p...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bd2c6aa3-8a0d-589f-91ca-f636f355a1d8
DOI: 10.21203/rs.3.rs-7512566/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Role and mechanism of palmitic acid-regulated palmitoylation modification of SEC63 protein during endoplasmic reticulum stress in Human Ovarian Granulosa Tumor Cells (KGN)DOI 10.21203/rs.3.rs-7512566/v1Read

ZDHHC17 participates in the pathogenesis of polycystic ovary syndrome by affecting androgen conversion to estrogen in granulosa cellsSemantic proximity Read

Palmitic acid-induced insulin resistance triggers granulosa cell senescence by disruption of the UPRmt/mitophagy/lysosome axisSemantic proximity Read

Evaluation and in vitro verification of the prognostic value of palmitoylation-related genes in ovarian cancerSemantic proximity Read

Proteomic changes in oocytes after in vitro maturation in lipotoxic conditions are different from those in cumulus cellsSemantic proximity Read

Lipid signalling dynamics of palmitate-induced endoplasmic reticulum stress in skeletal muscleSemantic proximity Read

TRIB3 Regulates FSHR Expression in Human Granulosa Cells Under High Levels of Free Fatty AcidsSemantic proximity Read

Metabolic molecular subtyping of ovarian cancer reveals the role of oleic acid-CD36 in facilitating cisplatin resistanceSemantic proximity Read

Mechanisms Driving Palmitate-Mediated Neuronal Dysregulation in the HypothalamusSemantic proximity Read

Endoplasmic reticulum stress increases exosome biogenesis and packaging relevant to sperm maturation in response to oxidative stress in obese miceSemantic proximity Read

Granulosa cell RNA-Seq insights into senescence and sphingolipid metabolism disorder in PCOS: aspirin as a potential therapeutic drugSemantic proximity Read

S-Palmitoylation as a Functional Regulator of Proteins Associated with Cisplatin Resistance in Bladder CancerSemantic proximity Read

Geranylgeranoic acid, a bioactive and endogenous fatty acid in mammals: a reviewSemantic proximity Read