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Article

Evidence for the Role of Mitochondrial DNA Release in the Inflammatory Response in Neurological Disorders.

International journal of molecular sciences - 29 Jun 2021

Moya Gonzalo E, Rivera Phillip D, Dittenhafer-Reed Kristin E

Abstract excerpt

Mitochondria are regarded as the metabolic centers of cells and are integral in many other cell processes, including the immune response. Each mitochondrion contains numerous copies of mitochondrial DNA (mtDNA), a small, circular, and bacterial-like DNA. In response to cellular damage or stress, mtDNA can be released from the mitochondrion and trigger immune and inflammatory responses. mtDNA release into the...

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Identifiers

PMID: 34209978
DOI: 10.3390/ijms22137030
PMCID: PMC8268735

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