Article

Chronic ER stress promotes cGAS/mtDNA-induced autoimmunity via ATF6 in myotonic dystrophy type 2

2022-06-28

Abstract excerpt

<title>Abstract</title> <p>Nucleic acid accumulation in repeat expansion disease poses multiple challenges to cellular integrity. Myotonic dystrophy type 2 (DM2) results from large CCTG repeats in the CNBP gene leading to myopathy and an increased prevalence of autoimmunity. Here, we observed that DM2 patients exhibited a type-I interferon signature in blood and cultured fibroblasts. RNA repeat accumulation was p...

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Literature Corpus work: ab44e5f7-fdc1-50de-aa04-de1117294b0e
DOI: 10.21203/rs.3.rs-1784722/v1

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