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Article

Persistent SARS-CoV-2 Spike is Associated with Localized Immune Dysregulation in Long COVID Gut Biopsies

2026-03-12

Abstract excerpt

SARS-CoV-2 persistence is a proposed driver of Long COVID (LC), but the in-situ relationship between residual viral antigen and immune dysregulation remains poorly defined. To address this critical gap, we employed a high-resolution, multi-modal approach—combining RNAscope, GeoMx Digital Spatial Profiling (DSP), spatial transcriptomics, and multiplex immunofluorescence—on 25 terminal ileum and left colon biopsies...

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Identifiers and source

Literature Corpus work
ab351976-0db1-5a4b-8667-8c93040bafba
DOI
10.64898/2026.03.09.707564
Open publication

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Persistent SARS-CoV-2 Spike is Associated with Localized Immune Dysregulation in Long COVID Gut BiopsiesDOI 10.64898/2026.03.09.707564
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