Article
Assessment of MTR Rs1805087 SNP as Possible Modifier of Sickle Cell Disease Severity in a Nigerian Population.
West African journal of medicine - 30 Nov 2022
Osunkalu V O, Ogbenna A A, Davies N O, Olowoselu F O, Aiyelokun O E, Akinsola O J, Taiwo I A
Abstract excerpt
BACKGROUND: Sickle cell disease is the commonest genetic disorder in Nigeria, affecting 2-3% of an estimated population of 160 million people. The role of genetic mutations in folate cycle genes, and the variable phenotypic expressions constituting disease severity, needs to be critically examined. OBJECTIVE: This study was carried out to establish the pattern of methionine synthase gene mutations (rs1805087...
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