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Extracellular HSP90 Machineries Build Tumor Microenvironment and Boost Cancer Progression

14 Oct 2021

Abstract excerpt

HSP90 is released by cancer cells in the tumor microenvironment where it associates with different co-chaperones generating complexes with specific functions, ranging from folding and activation of extracellular clients to the stimulation of cell surface receptors. Emerging data indicate that these functions are essential for tumor growth and progression. The understanding of the exact composition of...

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PMID: 34722515
DOI: 10.3389/fcell.2021.735529

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