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Direct targets of MEF2C are enriched for genes associated with schizophrenia and cognitive function and are involved in neuron development and mitochondrial function.

PLoS genetics - 1 Sept 2024

Ali Deema, Laighneach Aodán, Corley Emma, Patlola Saahithh Redddi, Mahoney Rebecca, Holleran Laurena, McKernan Declan P, Kelly John P, Corvin Aiden P, Hallahan Brian, McDonald Colm, Donohoe Gary, Morris Derek W

Abstract excerpt

Myocyte Enhancer Factor 2C (MEF2C) is a transcription factor that plays a crucial role in neurogenesis and synapse development. Genetic studies have identified MEF2C as a gene that influences cognition and risk for neuropsychiatric disorders, including autism spectrum disorder (ASD) and schizophrenia (SCZ). Here, we investigated the involvement of MEF2C in these phenotypes using human-derived neural stem cells...

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PMID: 39259737
DOI: 10.1371/journal.pgen.1011093
PMCID: PMC11419381

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