Article

The N34S mutation of SPINK1 may impact the kinetics of trypsinogen activation to cause early trypsin release in the pancreas

2020-08-23

Abstract excerpt

<h4>ABSTRACT</h4> The N34S variant of the trypsin inhibitor SPINK1 is the clinically most significant risk factor for chronic pancreatitis, but the underlying molecular mechanism could not be identified. Molecular dynamics simulations and docking of the generated conformational ensemble of SPINK1 to trypsin show that the mutation reduces the fraction of conformations that can directly participate in productive as...

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Literature Corpus work: aa71f4d2-ca9c-5bd4-95c5-37c0bd4a4ff7
DOI: 10.1101/2020.08.21.262162

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